Name: Tesamorelin / Ipamorelin
Brand: Essential Aminos
SKU: P-013
Price: 84.00 USD
Availability: InStock

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Chemical and Molecular Data for

Compound Name
Synonyms / Alt Names	; ;
CAS Number	804475-66-9
Chemical Formula	C₂₂₁H₃₆₆N₇₂O₆₇S
Molecular Weight	5136 g/mol
IUPAC Name	(4S)-4-[[2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,-[[(2S)-2-[[(2S)-3-carboxy-2-[[(2S)-2-[[(2S)-2-[[(E)-hex-3-enoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]propanoyl]amino]propanoyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]-3-carboxypropanoyl]amino]-3-methylpentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-hydroxypropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-5-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
InChIKey	QBEPNUQJQWDYKU-BMGKTWPMSA-N
SMILES Code	CC/C=C/CC(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N

Chemical and Molecular Data for

Compound Name
Synonyms / Alt Names	; ;
CAS Number	170851-70-4
Chemical Formula	C₃₈H₄₉N₉O₅
Molecular Weight	711.9 g/mol
IUPAC Name	(2S)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-[(2-amino-2-methylpropanoyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-naphthalen-2-ylpropanoyl]amino]-3-phenylpropanoyl]amino]hexanamide
InChIKey	NEHWBYHLYZGBNO-BVEPWEIPSA-N
SMILES Code	`CC(C)(C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@H](CC2=CC3=CC=CC=C3C=C2)C(=O)N[C@H](CC4=CC=CC=C4)C(=O)N[C@@H](CCCCN)C(=O)N)N`

What is the Blend?

The Blend is an advanced, dual-action peptide formulation combining two distinct growth hormone secretagogues in a precise 8MG / 2MG ratio. is a stabilized synthetic analog of growth hormone-releasing hormone (GHRH) modified with a trans-3-hexenoic acid group to extend its metabolic lifespan. is a highly selective pentapeptide ghrelin receptor agonist belonging to the growth hormone secretagogue (GHS) class. Together, they target alternative signaling pathways in the pituitary gland to induce a powerful, synergistic release of endogenous growth hormone. Researchers study this specific combination for its potential to accelerate visceral fat lipolysis, enhance lean muscle mass retention, and optimize cellular metabolic efficiency.

For laboratory and in vitro evaluation, researchers often choose to buy the Blend in high-purity lyophilized form. Reconstituted solutions can be securely prepared using specialized laboratory buffers or a compatible reconstitution solution to preserve peptide structure and prevent premature degradation during cellular validation screening.

What are the Mechanisms of Action?

The biochemical pathways and cellular targets of the Blend include:

Complementary Pituitary Pathway Activation: This formulation leverages a dual-signal mechanism. binds directly to growth hormone-releasing hormone receptors (GHRHR) on pituitary somatotropes to stimulate synthesis, while targets the growth hormone secretagogue receptor (GHS-R/ghrelin receptor). This simultaneous activation triggers an amplified, synergistic secretion cascade that far exceeds the performance of either peptide administered alone.
Lipolytic and Visceral Adipose Tissue Targeting: specifically stimulates peripheral lipolysis cascades. By escalating endogenous growth hormone availability, it downregulates fat storage enzymes and interacts directly with adipocyte receptors to promote the clearing of deep visceral adipose tissue (VAT).
Highly Selective Secretagogue Expression: Unlike traditional, less refined secretagogues, is exceptionally selective. It amplifies growth hormone pulse amplitudes while remaining completely inert at the receptors regulating cortisol, prolactin, or aldosterone, protecting the research environment from unwanted stress-hormone cross-reactivity.

What are the Clinical & Preclinical Trials on the Blend?

When evaluating research efficacy and published experimental literature for the Blend:

Visceral Fat Reduction Dynamics: Landmark clinical evaluations focusing on the component demonstrated highly significant, repeatable reductions in visceral adipose tissue and waist circumference metrics. The data confirmed substantial drops in deep trunk fat profiles alongside positive shifts in circulating insulin-like growth factor 1 (IGF-1) concentrations.
Pulsatile Secretion Stability: Preclinical screening models examining confirmed its unique ability to perfectly mimic natural, pulsatile growth hormone patterns. Rather than creating a flat baseline surge that risks pituitary receptor desensitization, it maintains healthy, default homeostatic endocrine feedback dynamics.
Synergistic Mass Optimization: In vitro tissue profiles and animal assays combining GHRH and GHS-R agonists show that simultaneous administration significantly improves nitrogen retention and cellular protein synthesis rates, accelerating muscle cell proliferation metrics compared to isolated controls.

How does the Blend compare to other compounds?

To evaluate absolute receptor affinity, signal duration, and tissue metabolic impacts, researchers compare the Blend against its individual components and alternative long-acting GHRH formulations:

Compound	Primary Target	Structural Modifications	Biological Impact / Receptor Affinity
Blend	GHRH Receptor & GHS-R (Ghrelin Receptor) simultaneously	8MG stabilized hexenoyl-GHRH analog paired with a 2MG selective pentapeptide secretagogue	Triggers an amplified, synergistic release of growth hormone; optimized for visceral fat reduction and muscle retention without stress-hormone cross-reactivity
(Standalone)	GHRH Receptor (Selective Agonist)	Human GHRH (1-44) sequence bound to a trans-3-hexenoic acid N-terminal anchor	Strong lipolytic action tailored specifically for visceral adipose tissue, but lacks the secondary amplification provided by ghrelin pathway activation
(Standalone)	GHS-R (Ghrelin Receptor Agonist)	Pure synthetic pentapeptide structure omitting traditional GHRH sequence configurations	Provides highly selective, clean pulsatile growth hormone releases, but its standalone performance is capped by the availability of baseline endogenous GHRH levels
	GHRH Receptor (Continuous Long-Acting Agonist)	Tetra-substituted GHRH (1-29) fragment modified with a C-terminal Drug Affinity Complex (DAC)	Binds covalently to serum albumin to yield a long biological half-life (6-8 days), creating a sustained elevate baseline release rather than mimicking rapid pulsatile dynamics

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Disclaimer: All compounds and research materials provided by Essential Aminos are strictly for laboratory and research professional use only. They are not approved for human or animal use nor consumption by the Food and Drug Administration (FDA). These products should not be used for any form of in vivo experimentation or for any other non-laboratory purpose. Any violation or indication of human or animal use will result in immediate removal from being able to purchase products in the future. By purchasing these products, you acknowledge that they will be used exclusively within a controlled and qualified research environment.

Certificate of Analysis

Certificates of analysis are provided for laboratory research reference. Expand a batch below to view the PDF. Only the newest three COAs for this product are listed here.

Search Batch / Lot / Search Code

8MG/2MG - Lot / Batch: BX-P-F9M6

Tested: Oct 10, 2026 · Purity: 99.77%