What is ?
(also known as Tyr-hGH Fragment 177-191) is a modified, synthetic 16-amino-acid peptide fragment derived from the C-terminal domain of human growth hormone (hGH). Originally designed through rational functional fragmentation, researchers sought to isolate the lipid-mobilizing properties of native hGH without triggering systemic growth-axis side effects or altered carbohydrate metabolism.
For laboratory and in vitro studies requiring high purity, researchers often choose to buy in lyophilized form. In addition, reconstituted solutions can be prepared using specialized laboratory buffers such as acetic acid to preserve peptide stability during experimental procedures.
Chemical and Molecular Data
| Compound Name | |
|---|---|
| Quantity | 5MG |
| Synonyms / Alt Names | ; ; |
| CAS Number | 221231-10-3 |
| Chemical Formula | C78H123N23O23S2 |
| Molecular Weight | 1815.1 g/mol |
| IUPAC Name | (2S)-2-[[2-[[(4R,7S,13S,16S,19S,22S,25R)-25-[[(2S)-5-amino-2-[[(2S)-2-[[(2S,-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylpentanoyl]amino]-3-methylbutanoyl]amino]-5-oxopentanoyl]amino]-22-(3-carbamimidamidopropyl)-13-(2-carboxyethyl)-7,19-bis(hydroxymethyl)-6,9,12,15,18,21,24-heptaoxo-16-propan-2-yl-1,2-dithia-5,8,11,14,17,20,23-heptazacyclohexacosane-4-carbonyl]amino]acetyl]amino]-3-phenylpropanoic acid |
| InChIKey | GVIYUKXRXPXMQM-BPXGDYAESA-N |
| SMILES Code | CC[C@H](C)[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCCNC(=N)N)CO)C(C)C)CCC(=O)O)CO)C(=O)NCC(=O)N[C@@H](CC2=CC=CC=C2)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC3=CC=C(C=C3)O)N |
What are the Mechanisms of Action?
The biochemical performance of the peptide hinges on its specific structural conformation. Key molecular mechanisms include:
- Adipose Lipolysis Modulation: Research demonstrates that stimulates lipolytic activity in adipose tissues by upregulating β3-adrenergic receptors and increasing catecholamine sensitivity, which in turn activates Hormone-Sensitive Lipase (HSL) to breakdown stored triglycerides.
- Inhibition of Lipogenesis: In addition to stimulating fat breakdown, experimental observations note its capacity to prevent the lipogenic conversion of non-fat food sources into adipose tissue.
- Absence of Growth Factors Elevation: Unlike full-length somatotropin, does not bind to the classical Growth Hormone Receptor (GHR) domain responsible for IGF-1 secretion, preventing hyperinsulinemia or unwanted mitogenic activity.
- Musculoskeletal & Chondrocyte Repair: Secondary investigation suggests potential regenerative pathways, including upregulation of extracellular matrix synthesis (Collagen II and Aggrecan) and suppression of matrix metalloproteinases (MMPs) via inhibition of the NF-κB signaling pathway.
What are the Clinical Trials on ?
When asking “Does work?”, researchers look to published clinical and preclinical literature:
- Metabolic & Obesity Research: Initial randomized clinical investigations evaluated oral and injectable administration protocols for weight management. Published clinical studies in Journal of Endocrinology and International Journal of Obesity revealed high safety tolerance, lack of adverse glycemic impact, and modest body weight reductions across subject groups.
- Joint & Cartilage Regeneration: Further evaluation documented in PubMed Central (PMC3584306) demonstrated that intra-articular administration of , especially in combination with hyaluronic acid, enhanced cartilage repair in animal models of osteoarthritis.
- Safety & Tolerability Profile: Across human clinical trials, demonstrated an excellent safety record, displaying no neutralizing antibodies, organ toxicity, or adverse changes in insulin sensitivity.
How does compare to other compounds?
To evaluate the efficacy and target profile of , researchers frequently compare it against structural variants and metabolic modulators:
Shipping & Returns
Same-Day Dispatch
Orders before 4 PM CT Mon–Fri ship same day. Weekend and holiday orders ship the next business day.
Carriers
U.S. shipping via FedEx. FedEx 2Day $15, FedEx Priority Overnight $60. Free shipping on U.S. orders over $200. Prices exclude tax.
Returns
Returns and exchanges for damaged or defective products only. Contact us within 14 days of delivery with your order number and photos.
Full details: Shipping Policy and Refund Policy.
Disclaimer: All compounds and research materials provided by Essential Aminos are strictly for laboratory and research professional use only. They are not approved for human or animal use nor consumption by the Food and Drug Administration (FDA). These products should not be used for any form of in vivo experimentation or for any other non-laboratory purpose. Any violation or indication of human or animal use will result in immediate removal from being able to purchase products in the future. By purchasing these products, you acknowledge that they will be used exclusively within a controlled and qualified research environment.
Certificate of Analysis
Certificates of analysis are provided for laboratory research reference. Expand a batch below to view the PDF. Only the newest three COAs for this product are listed here.
5MG - Lot / Batch: BX-P-I3F8
- Mass Identification: confirmed
- Average Net Peptide: 5.19 mg
- Average Purity: 99.663%
- Endotoxin Threshold Results: Pass (≤0.5 EU/mL)
- Lot#: BX-P-I3F8
5MG - Lot / Batch: BX-P-H9C4
- Mass Identification: confirmed
- Average Net Peptide: 2.99 mg
- Average Purity: 99.81%
- Endotoxin Threshold Results: Pass (Assay sensitivity ≤0.05 EU/mL; both replicates Pass)
- Lot#: BX-P-H9C4
- Search Code: Esse2608050816
Search all COAs by batch number (includes older batches not shown above).
