Skin Serum (Hyaluronic Acid, GHK-Cu, NAD+)
Chemical and Molecular Data for Hyaluronic Acid
| Compound Name | Hyaluronic Acid |
|---|---|
| Synonyms / Alt Names | Hyaluronan; Sodium hyaluronate |
| CAS Number | 9004-61-9 |
| Chemical Formula | (C14H21NO11)n |
| Molecular Weight | N/A |
| IUPAC Name | N/A |
| InChIKey | N/A |
| SMILES Code | N/A |
Chemical and Molecular Data for GHK-Cu
| Compound Name | GHK-Cu |
|---|---|
| Synonyms / Alt Names | Copper tripeptide; GHK-Cu; [N2-(N-Glycyl-L-histidyl)-L-lysinato(2-)]copper |
| CAS Number | N/A |
| Chemical Formula | C14H21CuN6O4– |
| Molecular Weight | 400.90 g/mol |
| IUPAC Name | copper (2S)-6-amino-2-[[(2S)-2-(2-azanidylacetyl)azanidyl-3-(1H-imidazol-4-yl)propanoyl]amino]hexanoate |
| InChIKey | LREZPQNYQZAPJC-ACMTZBLWSA-L |
| SMILES Code | C1=C(N=CN1)C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)[O-])[N-]C(=O)C[NH-].[Cu+2] |
Chemical and Molecular Data for NAD+
| Compound Name | NAD+ |
|---|---|
| Synonyms / Alt Names | nadide; coenzyme I; beta-NAD |
| CAS Number | 64417-72-7 |
| Chemical Formula | C21H27N7O14P2 |
| Molecular Weight | 663.4 g/mol |
| IUPAC Name | [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate |
| InChIKey | BAWFJGJZGIEFAR-NNYOXOHSSA-N |
| SMILES Code | C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)([O-])OP(=O)(O)OC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N |
What is Pure Skin Serum by Essential Aminos?
Essential Amino’s Pure Skin Serum is an advanced, multi-targeted dermatological research formulation engineered for localized cellular repair, extracellular matrix remodeling, and deep dermal bioenergetics. This synergistic serum combines high-concentration GHK-Cu, NAD+, and Hyaluronic Acid within a bio-compatible, liquid carrier vehicle composed of Glycerin, Reverse Osmosis (RO) Water, and the antimicrobial cosmetic preservative Germall Plus. Because this product is delivered as a fully solubilized, ready-to-apply liquid matrix, it does not require a reconstitution solution prior to deployment in laboratory assays.
For laboratory and in vitro evaluation, researchers often choose to buy Pure Skin Serum by Essential Aminos to analyze multi-pathway tissue restoration across cultured epidermal and dermal skin models. Because active pyridine nucleotides and copper tripeptides are sensitive to thermal degradation, Pure Skin Serum must be kept refrigerated (2°C to 8°C) when not in use to maintain complete coenzyme stability and prevent oxidative degradation of the active peptide complex.
What are the Mechanisms of Action?
The biochemical pathways and cellular targets of Pure Skin Serum include:
- GHK-Cu Extracellular Matrix Remodeling: Copper Tripeptide-1 (GHK-Cu) stimulates fibroblast proliferation, upregulates collagen and elastin synthesis, and modulates metalloproteinase enzymes (MMPs) to clear damaged structural proteins and accelerate tissue repair.
- NAD+ Dermal Bioenergetics & DNA Repair: Topical NAD+ penetrates dermal cell layers to replenish intracellular pyridine pools. It acts as an obligatory co-substrate for Sirtuin enzymes (SIRT1) and Poly(ADP-ribose) Polymerases (PARPs), driving cellular survival responses, mitigating UV-induced oxidative strain, and supporting mitochondrial ATP synthesis.
- Hyaluronic Acid Hydration & Carrier Transport: Hyaluronic Acid creates a viscoelastic extracellular hydrogel matrix that binds up to 1,000 times its weight in water. Combined with Glycerin, it enhances epidermal barrier hydration and optimizes passive transdermal flux for the active GHK-Cu and NAD+ molecules.
What are the Laboratory Research Applications on Pure Skin Serum?
When evaluating research efficacy and published experimental literature for Pure Skin Serum:
- Copper Tripeptide Dermal Density Assays: In vitro and ex vivo human skin culture evaluations confirm that topical GHK-Cu significantly increases dermal procollagen synthesis, leading to measurable increases in skin thickness, improved elasticity, and accelerated epithelial cell migration.
- Dermal NAD+ Flux and Photoprotection Models: Preclinical trials tracking topical NAD+ applications in oxidative stress models demonstrate that maintaining elevated local NAD+ levels suppresses UV-induced apoptosis, restores cellular energy metabolism, and prevents microvascular inflammatory breakdown.
- Thermal Stability & Preservation Screening: Analytical chemistry reviews confirm that preserving the liquid serum under strict refrigeration (2°C to 8°C) prevents temperature-induced hydrolysis of the NAD+ dinucleotide and preserves the chelation binding state of GHK-Cu, ensuring long-term batch potency.
How does Pure Skin Serum compare to other compounds?
To evaluate multi-target synergy, bioenergetic efficiency, and delivery mechanics, researchers compare Pure Skin Serum against single-active topical formulations and standard peptide bases:
| Compound | Primary Target | Structural Modifications / Key Actives | Biological Impact / Receptor Affinity |
|---|---|---|---|
| Pure Skin Serum | Fibroblast Collagen Cascades, Sirtuin/PARP DNA Repair, & Epidermal Hydration | Multi-active matrix: GHK-Cu, NAD+, HA in Glycerin/RO Water/Germall Plus | Delivers triple-action dermal repair; combines structural remodeling, metabolic energy replenishment, and barrier hydration in a single refrigerated liquid format |
| GHK-Cu | Fibroblast Activation & Extracellular Matrix Remodeling | Isolated Copper Tripeptide-1 sequence in standard aqueous base | Promotes targeted collagen synthesis and wound healing, but lacks direct coenzyme support for intracellular DNA repair and mitochondrial bioenergetics |
| NAD+ | PARP DNA Repair Enzymes & SIRT1 Longevity Pathways | Single-active Nicotinamide Adenine Dinucleotide in liquid vector | Replenishes cellular NAD+ pools to mitigate oxidative photo-aging, but does not directly stimulate structural extracellular matrix remodeling or deep collagen synthesis |
Shipping & Returns
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Disclaimer: All compounds and research materials provided by Essential Aminos are strictly for laboratory and research professional use only. They are not approved for human or animal use nor consumption by the Food and Drug Administration (FDA). These products should not be used for any form of in vivo experimentation or for any other non-laboratory purpose. Any violation or indication of human or animal use will result in immediate removal from being able to purchase products in the future. By purchasing these products, you acknowledge that they will be used exclusively within a controlled and qualified research environment.
Certificate of Analysis
Certificates of analysis are provided for laboratory research reference. Expand a batch below to view the PDF. Only the newest three COAs for this product are listed here.
No certificate of analysis is currently linked to this product. Search by batch number on the COA Search page.
