Lipo-C+ w/NAD+ (Lipotropic Blend)
Chemical and Molecular Data for L-Methionine
| Compound Name | L-Methionine |
|---|---|
| Synonyms / Alt Names | h-Met-oh; (S)-2-Amino-4-(methylthio)butanoic acid; Cymethion |
| CAS Number | 58576-49-1 |
| Chemical Formula | C5H11NO2S |
| Molecular Weight | 149.21 g/mol |
| IUPAC Name | (2S)-2-amino-4-methylsulfanylbutanoic acid |
| InChIKey | FFEARJCKVFRZRR-BYPYZUCNSA-N |
| SMILES Code | CSCC[C@@H](C(=O)O)N |
Chemical and Molecular Data for L-Inositol
| Compound Name | L-Inositol |
|---|---|
| Synonyms / Alt Names | an inositol; Scyllo-inositol; myo-inositol |
| CAS Number | 38876-99-2 |
| Chemical Formula | C6H12O6 |
| Molecular Weight | 180.16 g/mol |
| IUPAC Name | cyclohexane-1,2,3,4,5,6-hexol |
| InChIKey | CDAISMWEOUEBRE-UHFFFAOYSA-N |
| SMILES Code | C1(C(C(C(C(C1O)O)O)O)O)O |
Chemical and Molecular Data for CDP-Choline
| Compound Name | CDP-Choline |
|---|---|
| Synonyms / Alt Names | cytidine 5'-diphosphocholine; CDP-choline; citicholine |
| CAS Number | 987-78-0 |
| Chemical Formula | C14H26N4O11P2 |
| Molecular Weight | 488.32 g/mol |
| IUPAC Name | [[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] 2-(trimethylazaniumyl)ethyl phosphate |
| InChIKey | RZZPDXZPRHQOCG-OJAKKHQRSA-N |
| SMILES Code | C[N+](C)(C)CCOP(=O)([O-])OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=CC(=NC2=O)N)O)O |
Chemical and Molecular Data for L-Carnitine
| Compound Name | L-Carnitine |
|---|---|
| Synonyms / Alt Names | Levocarnitine; Carnitor; vitamin BT |
| CAS Number | 44985-71-9 |
| Chemical Formula | C7H15NO3 |
| Molecular Weight | 161.20 g/mol |
| IUPAC Name | (3R)-3-hydroxy-4-(trimethylazaniumyl)butanoate |
| InChIKey | PHIQHXFUZVPYII-ZCFIWIBFSA-N |
| SMILES Code | C[N+](C)(C)C[C@@H](CC(=O)[O-])O |
Chemical and Molecular Data for Methylcobalamin (B12)
| Compound Name | Methylcobalamin (B12) |
|---|---|
| Synonyms / Alt Names | Mecobalamin; MSK1589; CCG-270675 |
| CAS Number | 13422-55-4 |
| Chemical Formula | C63H91CoN13O14P |
| Molecular Weight | 1344.4 g/mol |
| IUPAC Name | carbanide;cobalt(3+);[(2R,3S,4R,5S)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] 1-[3-[(1R,2R,3R,5Z,7S,10Z,12S,13S,15Z,17S,18S,19R)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-24-id-3-yl]propanoylamino]propan-2-yl phosphate |
| InChIKey | ZFLASALABLFSNM-WYVZQNDMSA-L |
| SMILES Code | [CH3-].CC1=CC2=C(C=C1C)N(C=N2)[C@@H]3[C@@H]([C@@H]([C@H](O3)CO)OP(=O)([O-])OC(C)CNC(=O)CC[C@@]4([C@H]([C@@H]5[C@]6([C@@]([C@@H](/C(=C(/C7=N/C(=CC8=N/C(=C(C4=N5)/C)/[C@H](C8(C)C)CCC(=O)N)/[C@H]([C@]7(C)CC(=O)N)CCC(=O)N)C)/[N-]6)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[Co+3] |
Chemical and Molecular Data for Pyridoxine (B6)
| Compound Name | Pyridoxine (B6) |
|---|---|
| Synonyms / Alt Names | Pyridoxol; Pyridoxin; 3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine |
| CAS Number | 12001-77-3 |
| Chemical Formula | C8H11NO3 |
| Molecular Weight | 169.18 g/mol |
| IUPAC Name | 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol |
| InChIKey | LXNHXLLTXMVWPM-UHFFFAOYSA-N |
| SMILES Code | CC1=NC=C(C(=C1O)CO)CO |
Chemical and Molecular Data for NAD+
| Compound Name | NAD+ |
|---|---|
| Synonyms / Alt Names | nadide; coenzyme I; beta-NAD |
| CAS Number | 64417-72-7 |
| Chemical Formula | C21H27N7O14P2 |
| Molecular Weight | 663.4 g/mol |
| IUPAC Name | [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate |
| InChIKey | BAWFJGJZGIEFAR-NNYOXOHSSA-N |
| SMILES Code | C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)([O-])OP(=O)(O)OC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N |
What is Lipo-C+ w/NAD+?
Lipo-C+ w/NAD+ is an advanced, multi-component liquid lipotropic blend of amino acids engineered to support cellular ATP production, hepatic lipid transport, and mitochondrial fatty acid oxidation intended for in vitro laboratory research models. Building upon the traditional lipotropic blend of amino acids, MIC (Methionine, Inositol, Choline) and MIC B12 formulations, Lipo-C+ w/NAD+ integrates high-potency metabolic cofactors into a single, pre-solubilized matrix. Each 20mL multi-use vial delivers a precisely calibrated concentration of L-Methionine (10mg/ml), L-Inositol (50mg/ml), CDP Choline (50mg/ml), L-Carnitine (250mg/ml), Vitamin B12 (methylcobalamin) (500mcg/ml), Vitamin B6 (25mg/ml), and NAD+ (20mg/ml).
Manufactured and 3rd-party tested in the USA within an ISO-certified cleanroom, our lipotropic blend of amino acids, NAD+, and L-Carnitine adheres to stringent analytical purity and stability standards. Researchers investigate this comprehensive lipotropic blend across cellular assays and metabolic research models to analyze the convergence of lipid mobilization, acetylcholine biosynthesis, and mitochondrial bioenergetics.
Formulation and Concentration Data
| Product Name | Lipo-C+ w/NAD+ Lipotropic Blend |
|---|---|
| Container Configuration | 20mL Multi-Use Liquid Vial |
| Manufacturing Standards | Manufactured & 3rd-Party Tested in the USA (ISO-Certified Cleanroom) |
| Active Ingredients & Concentrations | L-Methionine — 10mg/ml L-Inositol — 50mg/ml CDP Choline — 50mg/ml L-Carnitine — 250mg/ml Vitamin B12 (methylcobalamin) — 500mcg/ml Vitamin B6 — 25mg/ml NAD+ — 20mg/ml |
| Product Class | Lipotropic & Amino Acid Blends / Metabolic Cofactor Matrix |
| Storage Requirements | Store Refrigerated (2°C to 8°C); Protect from Light and Freezing |
What are the Mechanisms of Action?
The biochemical pathways and cellular targets to evaluate:
- Hepatic Lipid Mobilization & Methylation Cascades: L-Methionine serves as an essential sulfur-containing lipotropic amino acid that acts as a precursor to S-adenosylmethionine (SAMe). In combination with L-Inositol and CDP Choline, it facilitates the export of triglycerides from hepatic tissue by supporting phosphatidylcholine synthesis, preventing abnormal lipid accumulation within hepatocyte cultures.
- Mitochondrial Fatty Acid Transport & Coenzyme Repletion: High-concentration L-Carnitine (250mg/ml) acts as an obligatory acyl-CoA shuttle, transporting long-chain fatty acids across the inner mitochondrial membrane for beta-oxidation. Concurrently, NAD+ (20mg/ml) provides the vital oxidizing coenzyme required by Complex I of the electron transport chain and sirtuin deacetylases (SIRT1/SIRT3), elevating cellular ATP output.
- Neuro-Metabolic Cofactor Support & Acetylcholine Biosynthesis: CDP Choline provides bioavailable choline to support phospholipid membrane integrity and acetylcholine synthesis. Vitamin B6 (pyridoxal-5-phosphate precursor) and bioactive Vitamin B12 (methylcobalamin) act as fundamental enzymatic cofactors in transsulfuration, homocysteine remethylation, and amino acid metabolic pathways.
What are the Clinical & Preclinical Trials on Lipo-C+ w/NAD+ Components?
When evaluating research efficacy and published experimental literature for a liquid lipotropic blend of amino acids:
- Lipotropic Transport and Hepatic Metabolism Studies: Experimental research published in ScienceDirect highlights how lipotropic compounds modulate hepatic lipid accumulation, demonstrating that adequate availability of methyl donors and Carnitine derivatives enhances cellular fatty acid oxidation rates and prevents lipid-induced metabolic stress.
- Choline and Methionine Interaction Assays: Metabolic investigations detailed in PMC (PMC1275350) evaluate the interdependent pathways of choline, methionine, and methyl group donors. The literature confirms that combined lipotropic availability optimizes one-carbon metabolism, reduces intracellular oxidative stress markers, and maintains cellular membrane phospholipid stability.
- Cleanroom Quality & Analytical Testing Standards: Batch verification and stability testing confirm that manufacturing Lipo-C+ w/NAD+ within an ISO-certified cleanroom in the USA ensures complete chemical uniformity, zero particulate contamination, and stable bio-activity across all active ingredients throughout the product shelf life.
How does Lipo-C+ w/NAD+ compare to other lipotropic blends of amino acids?
To evaluate formulation complexity, ingredient synergy, and research utility, researchers compare Lipo-C+ w/NAD+ against traditional lipotropic mixtures and isolated metabolic agents:
| Formulation / Product | Key Ingredients | Primary Mechanisms | Research Profile & Focus |
|---|---|---|---|
| Lipo-C+ w/NAD+ (20mL Vial) | L-Methionine, L-Inositol, CDP Choline, L-Carnitine, Methylcobalamin B12, Vitamin B6, NAD+ | Multi-target lipotropic transport, mitochondrial beta-oxidation, acetylcholine support, and NAD+ coenzyme repletion | Comprehensive lipotropic blend providing maximum ingredient synergy across lipid metabolism and mitochondrial energy assays |
| Traditional MIC B12 | Methionine, Inositol, Choline, Cyanocobalamin B12 | Basic hepatic lipid export and B12 cofactor supplementation | Standard baseline lipotropic mixture; lacks L-Carnitine fatty acid transport, CDP Choline neuro-support, and NAD+ bioenergetic input |
| L-Carnitine | L-Carnitine | Mitochondrial fatty acid transport via carnitine palmitoyltransferase (CPT) shuttles | Focuses exclusively on long-chain fatty acid translocation into the mitochondrial matrix without supplemental lipotropic methyl donors or B-complex cofactors |
Frequently Asked Questions (FAQs)
1. What makes Lipo-C+ w/NAD+ different from standard MIC or MIC B12 formulations?
While standard MIC formulations contain only Methionine, Inositol, Choline, and B12, Lipo-C+ w/NAD+ expands this core lipotropic blend by adding L-Carnitine (250mg/ml) for mitochondrial fatty acid shuttling, NAD+ (20mg/ml) for cellular redox support, CDP Choline for enhanced acetylcholine pathway research, and Vitamin B6 for amino acid enzymatic conversion.
2. Where is Lipo-C+ w/NAD+ manufactured and tested?
Lipo-C+ w/NAD+ is fully manufactured, sterile-filtered, and 3rd-party tested in the USA within an ISO-certified cleanroom facility. Every production batch undergoes strict quality control assays to verify exact compound concentrations, sterility, and the absence of endotoxins or heavy metals.
3. What role does NAD+ play within a liquid lipotropic blend?
NAD+ (Nicotinamide Adenine Dinucleotide) acts as a vital coenzyme in cellular respiration. In a lipotropic blend, NAD+ supports the enzymatic breakdown of fatty acids in the mitochondria, serving as a primary electron acceptor during ATP synthesis and activating sirtuin enzymes involved in cellular metabolic regulation.
4. Why is CDP Choline utilized in Lipo-C+ alongside inositol and methionine?
CDP Choline (Cytidine 5′-diphocholine) provides a highly stable source of both choline and cytidine. In laboratory research models, it supports the rate-limiting step of phosphatidylcholine synthesis for cell membranes and serves as an efficient donor for acetylcholine neurotransmitter biosynthesis pathways.
5. What are the proper storage and handling parameters for the 20mL Lipo-C+ multi-use vial?
The 20mL multi-use Lipo-C+ liquid vial should be stored under refrigeration (2°C to 8°C), kept protected from light, and extreme temperature fluctuations. Because the liquid solution is pre-solubilized, it does not require an external reconstitution solution before deployment in laboratory research assays.
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Disclaimer: All compounds and research materials provided by Essential Aminos are strictly for laboratory and research professional use only. They are not approved for human or animal use nor consumption by the Food and Drug Administration (FDA). These products should not be used for any form of in vivo experimentation or for any other non-laboratory purpose. Any violation or indication of human or animal use will result in immediate removal from being able to purchase products in the future. By purchasing these products, you acknowledge that they will be used exclusively within a controlled and qualified research environment.
Certificate of Analysis
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