DSIP (Delta Sleep-Inducing Peptide)
What is DSIP (Delta-sleep inducing peptide)?
DSIP (also known as Delta Sleep-Inducing Peptide or Emideltide) is a naturally occurring nonapeptide found in the brain that demonstrates the ability to cross the blood-brain barrier. Originally discovered in 1977 by Swiss researchers monitoring cerebral venous blood during slow-wave sleep induction, researchers investigate this compound for its multi-system regulatory properties, particularly its impact on sleep architecture and cellular stress mitigation.
For laboratory and in vitro evaluation, researchers often choose to buy DSIP in high-purity lyophilized form. In addition, reconstituted solutions can be prepared using specialized laboratory buffers such as reconstitution solution to preserve peptide stability during complex experimental protocols.
Chemical and Molecular Data
| Compound Name | DSIP (Delta Sleep-Inducing Peptide) |
|---|---|
| Quantity | 5MG / 10MG |
| Synonyms / Alt Names | Emideltide; DSIP nonapeptide; DELTA SLEEP-INDUCING PEPTIDE |
| CAS Number | 62568-57-4, 69431-45-4 |
| Chemical Formula | C35H48N10O15 |
| Molecular Weight | 848.8 g/mol |
| IUPAC Name | (2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]acetyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]pentanedioic acid |
| InChIKey | ZRZROXNBKJAOKB-GFVHOAGBSA-N |
| SMILES Code | C[C@@H](C(=O)NCC(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)O)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)N |
What are the Mechanisms of Action?
The biochemical pathways and cellular targets of DSIP include:
- Delta-Wave Induction: Comprehensive repository records compiled by Science.gov demonstrate that DSIP modulates central GABAergic, glutamatergic, and serotonergic pathways to promote slow-wave delta EEG patterns in isolated brain tissues.
- HPA Axis Regulation: In addition to primary somnogenic pathways, experimental observations note that DSIP acts as a neuromodulator that reduces corticotropin-releasing hormone (CRH) release under induced laboratory stress models.
- Oxidative Stress Control: Studies indicate a targeted neuroprotective profile, where the peptide aids in maintaining homeostatic antioxidant enzyme activity (such as superoxide dismutase) during cellular sleep deprivation testing.
What are the Clinical & Preclinical Trials on DSIP (Emideltide)?
When evaluating research efficacy and published experimental literature for DSIP (Emideltide):
- Human Physiological Monitoring: Investigations published in PubMed evaluated the compound’s impact on human sleep architectures, observing that while it safely promotes sleep onset and delta-wave density, it does not distort the natural distribution of REM or slow-wave sleep cycles.
- Circadian and Endocrine Stability: Preclinical evaluations tracked via Science.gov data streams demonstrated consistent dose-response trends in normalizing physiological rhythm disruptions brought on by artificial environmental variations.
- Safety & Tolerability Profile: Across laboratory evaluations, DSIP demonstrated a broad toxicological safety window, high purity metrics, and a total absence of residual morning motor impairment or sedative toxicity across live research subjects.
How does DSIP compare to other compounds?
To evaluate target specificity and relative potency, researchers compare DSIP against traditional physiological sleep markers and broader cognitive support formulations:
| Compound | Primary Target | Structural Modifications | Biological Impact / Receptor Affinity |
|---|---|---|---|
| DSIP (Emideltide) | GABA/Glutamate Modulator & HPA Axis Regulator | Endogenous Nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) layout | Promotes deep delta-wave architecture and stress recovery without rapid sedative receptor down-regulation |
| Melatonin | MT1 & MT2 G-Protein Coupled Receptors | Indoleamine core structure derived from tryptophan metabolism | Synchronizes circadian clock signaling phase shifts rather than directly altering specific wave amplitudes |
| Melts Brain Fuel Dissolving Strips | Multi-Pathway Cognitive & Neuro-Nutrient Matrix | Orally dissolving complex incorporating synergistic metabolic precursors | Provides direct fuel substrates to baseline cognitive metabolic pathways, contrasting with DSIP’s isolated peptide regulatory role |
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| Specification | Value |
|---|---|
| Size | 5mg, 10mg |
Certificate of Analysis
Certificates of analysis are provided for laboratory research reference. Expand a batch below to view the PDF. Only the newest three COAs for this product are listed here.
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